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Article

Proteome-wide Mendelian randomization and colocalization analysis identify potential drug targets for psoriasis

2023-08-22

Abstract excerpt

<title>Abstract</title> <p>Psoriasis is a prevalent chronic inflammatory disease of the skin. New psoriasis therapy targets are required. 18 causative proteins were discovered in this study employing proteome-wide Mendelian randomization analysis by integration of the largest-to-date GWASs of plasma protein. Five proteins (namely APOF, MAPRE1, GCKR, ATF6B, and PRSS8) were found to have high support for colocaliza...

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Identifiers and source

Literature Corpus work
5c228bec-b193-5209-a30f-917330d46723
DOI
10.21203/rs.3.rs-3280280/v2
Open publication

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Proteome-wide Mendelian randomization and colocalization analysis identify potential drug targets for psoriasisDOI 10.21203/rs.3.rs-3280280/v2
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