Article

Reconstructing subclonal composition and evolution from whole genome sequencing of tumors

2014-06-27

Abstract excerpt

Tumors often contain multiple, genetically distinct subpopulations of cancerous cells. These so-called subclonal populations are defined by distinct somatic mutations that include point mutations such as single nucleotide variants and small indels - collectively called simple somatic mutations (SSMs) - as well as larger structural changes that result in copy number variations (CNVs). In some cases, the genotype an...

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Literature Corpus work: 89f3ee43-fd7c-54df-9a0c-acd421260142
DOI: 10.1101/006692

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