Article

Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against <i>Aspergillus fumigatus</i>

2025-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Fosmanogepix is a new antifungal agent currently undergoing phase 3 clinical trials. Its active moiety, manogepix, inhibits Gwt1 which is an enzyme essential for the assembly and attachment of glycosylphosphatidylinositol anchors to cell wall proteins. Manogepix has a strong fungistatic activity against most human pathogenic fungal species. Here we characterized the activity of manogepix against...

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Literature Corpus work: 89e3fd87-8f5d-5af9-ba36-7e0257d75f1a
DOI: 10.1101/2025.10.20.683572

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