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A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration

2021-07-24

Abstract excerpt

<title>Abstract</title> <p>Background: Preclinical and clinical studies support a strong association between mutations in the GBA1 gene that encodes beta-glucocerebrosidase (GCase) (EC 3.2.1.45; glucosylceramidase beta) and Parkinson’s disease (PD). Alpha-synuclein (AS), a key player in PD pathogenesis, and GBA1 mutations may independently and synergistically cause lysosomal dysfunction and thus, embody clinicall...

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Literature Corpus work
8e5f611a-ecd8-5406-b0dc-b0d78d1ed6f0
DOI
10.21203/rs.3.rs-721944/v1
Open publication

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A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degenerationDOI 10.21203/rs.3.rs-721944/v1
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