Article

Whole-Process 3D ECM-Encapsulated Organoid-Based Automated High-Throughput Screening Platform Accelerates Drug Discovery for Rare Diseases

2024-10-12

Abstract excerpt

The use of organoids, especially patient-derived organoids, for high-throughput screening (HTS) is widely accepted due to their ability to mimic the three-dimensional (3D) structure, function, and drug responses of in vivo tissues. However, the complexity of handling extracellular matrix (ECM) components with traditional HTS devices leads to the utilization of suspension cultures in matrix-free or matrix-low condi...

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Literature Corpus work: 89bdbcbd-e0c2-54fc-8035-efb088534289
DOI: 10.1101/2024.10.08.617181

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