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Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

10 Jul 2020

Abstract excerpt

The recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal approach for drug discovery. However, organoid culturing with extracellular matrix to support 3D architecture has been challenging for high-throughput screening (HTS)-based drug discovery due to technical difficulties. Using...

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PMID: 32678871
DOI: 10.1093/jmcb/mjaa036

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