Article

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

2022-04-12

Abstract excerpt

SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition in tropism from olfactory to respiratory epithelium as the virus evolved. Analyzing each variants revealed that SARS-CoV-2 WA1 or Delta infects a proportion of olfactory neurons...

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Literature Corpus work: 899a4810-774a-5c26-b701-3bf24684c15f
DOI: 10.1101/2022.04.12.487379

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