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SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

16 Jul 2021

Abstract excerpt

Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. Here we examine the functional and structural consequences of SARS-CoV-2 infection in a reconstructed human bronchial epithelium model. SARS-CoV-2 replication causes a transient decrease in epithelial barrier function and disruption of tight junctions, though viral particle...

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PMID: 34272374
DOI: 10.1038/s41467-021-24521-x

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