Article

Uncovering strain- and age-dependent differences in innate immune response to SARS-CoV-2 infection in nasal epithelia using 10X single-cell sequencing

2023-03-06

Abstract excerpt

<h4>Summary</h4> Assessing the impact of SARS-CoV-2 variants on the host is crucial with continuous emergence of new variants. We employed single-cell sequencing to investigate host transcriptomic response to ancestral and Alpha-strain SARS-CoV-2 infections within air-liquid-interface human nasal epithelial cells from adults and adolescents. Strong innate immune responses were observed across lowly-infected and b...

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Literature Corpus work: 83331d53-83a9-5265-9228-0a1e45817908
DOI: 10.1101/2023.03.04.531075

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