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A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

26 Jun 2019

Abstract excerpt

Dengue is the most widespread vector-borne viral disease caused by dengue virus (DENV) for which there are no safe, effective drugs approved for clinical use. Here, by using sequential antigen panning of a yeast antibody library derived from healthy donors against the DENV envelop protein domain III (DIII) combined with depletion by an entry defective DIII mutant, we identified a cross-reactive human monoclonal...

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PMID: 31242272
DOI: 10.1371/journal.ppat.1007836

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