Article

Generation and therapeutic efficacy of the novel Fc-modified cross-neutralizing human monoclonal antibodies against dengue virus

2023-05-26

Abstract excerpt

<h4>Background: </h4> Dengue disease is a mosquito-borne infection caused by four dengue virus serotypes (DENV1–4). Secondary infections can produce flavivirus cross-reactive antibodies at sub-neutralizing levels. This phenomenon can significantly increase the severity of secondary infections via antibody-dependent enhancement (ADE). ADE activity is associated with a high risk of viral infection in immune effector...

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Literature Corpus work: 9f62b88d-7f0f-5a67-a8cf-95adfece7fe8
DOI: 10.1101/2023.05.25.542225

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