Article

PGC-1β prevents statin-associated myotoxicity in oxidative skeletal muscle

2017-11-13

Abstract excerpt

Statins are generally well-tolerated, but can induce myopathy. Statins are associated with impaired expression of PGC-1β in human and rat skeletal muscle. The current study was performed to investigate the relation between PGC-1β expression and function and statin-associated myopathy. In WT mice, atorvastatin impaired mitochondrial function in glycolytic, but not in oxidative muscle. In PGC-1β KO mice, atorvastati...

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Literature Corpus work: 8985be77-09af-5ac8-b706-d8c3d066566a
DOI: 10.1101/218636

Open publication

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