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Article

Activation of the tissue factor-dependent extrinsic pathway and its relation to JAK2 V617F mutation status in patients with essential thrombocythemia.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Oct 2016

Gadomska Grażyna, Stankowska Katarzyna, Boinska Joanna, Bartoszewska-Kubiak Alicja, Haus Olga, Rość Danuta

Abstract excerpt

Thrombotic complications may occur in 7.6-29.4% of patients with essential thrombocythemia. According to the cellular theory, tissue factor (TF) activating extrinsic blood coagulation pathway is essential for the activation of blood clotting. The aim of the study was to evaluate the activation of the TF-dependent extrinsic pathway in patients with essential thrombocythemia, depending on the presence or absence of...

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Identifiers

PMID: 26945263
DOI: 10.1097/MBC.0000000000000551

Genes

JAK2
TFPI

Variants

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