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Article

Implications of <i>TP53</i> Allelic State for Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes

2019-12-19

Abstract excerpt

<h4>ABSTRACT</h4> TP53 mutations are associated with poor clinical outcomes and treatment resistance in myelodysplastic syndromes. However, the biological and clinical relevance of the underlying mono- or bi-allelic state of the mutations is unclear. We analyzed 3,324 MDS patients for TP53 mutations and allelic imbalances of the TP53 locus and found that 1 in 3 TP53 -mutated patients had mono-allelic targeting...

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Literature Corpus work
f8b55cd9-78d3-5616-a796-878d677ba0f8
DOI
10.1101/2019.12.19.868844
Open publication

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Implications of <i>TP53</i> Allelic State for Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic SyndromesDOI 10.1101/2019.12.19.868844
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