Article

Variant-Level Functional Classification of Monoallelic TP53 Mutations Refines Prognostic Stratification in Myelodysplastic Neoplasms Beyond Allelic Status

2026-03-20

Abstract excerpt

TP53 mutations represent one of the strongest adverse prognostic factors in myelodysplastic neoplasms (MDS). While multi-hit TP53 ( TP53 multiHit ) alterations uniformly lead to very poor outcomes, the prognostic relevance of monoallelic TP53 ( TP53 mono ) mutations remains controversial. TP53 variants can cause loss-of-function, dominant-negative, or gain-of-function effects. We hypothesized that functiona...

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Literature Corpus work: 7ac759b3-3110-5735-a4b4-a338ad7fd79b
DOI: 10.64898/2026.03.18.26348425

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