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Article

Genetic and Clinical Features in TP53-Mutated Patients With Myelodysplastic Neoplasms: A Retrospective Study Based on Next-Generation Sequencing Data.

Cancer reports (Hoboken, N.J.) - 1 Jun 2026

Cheng Yanming, Liu Lixia, Gao Yu, Wang Yifei, Zhu Wei, Chen Hong, Qin Jiayue, Zhang Yudi

Abstract excerpt

BACKGROUND: The recent fifth edition of World Health Organization and International Consensus Classification in 2022 recognized TP53-mutated myelodysplastic neoplasms (MDS) as a distinct entity requiring multi-hit classification. Literatures indicate that TP53 variant alle frequency (VAF) correlates with clinical outcomes. However, comprehensive studies that characterize the full mutation landscape and clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42213496
DOI: 10.1002/cnr2.70584
PMCID: PMC13239453

Genes

TP53
ASXL1
DNMT3A
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Genetic and Clinical Features in TP53-Mutated Patients With Myelodysplastic Neoplasms: A Retrospective Study Based on Next-Generation Sequencing Data.PMID 42213496Read ↗

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