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Article

A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.

Journal of the American Chemical Society - 16 Apr 2008

Engel Stanislav, Skoumbourdis Amanda P, Childress John, Neumann Susanne, Deschamps Jeffrey R, Thomas Craig J, Colson Anny-Odile, Costanzi Stefano, Gershengorn Marvin C

Abstract excerpt

Virtual screening has become a major focus of bioactive small molecule lead identification, and reports of agonists and antagonists discovered via virtual methods are becoming more frequent. G protein-coupled receptors (GPCRs) are the one class of protein targets for which success with this approach has been limited. This is likely due to the paucity of detailed experimental information describing GPCR structure...

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PMID: 18357984
DOI: 10.1021/ja077620l

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TRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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