Article

N-terminal acetylation reduces α-synuclein pathology in models of Parkinson’s disease

2025-11-21

Abstract excerpt

The α-synuclein protein, encoded by SNCA gene, is a major constituent of pathological intracellular inclusions such as Lewy bodies found in the brains of patients with Parkinson’s disease and other synucleinopathies. Whereas α-synuclein phosphorylation has been much studied, comparatively less work has been devoted to other post-translational modifications such as acetylation, especially given that N-terminally a...

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Literature Corpus work: 71e18420-4a13-561c-aa8a-060bc7d0eb99
DOI: 10.1101/2025.11.21.689703

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