Article

Impact of Frequent ARID1A Mutations on Protein Stability: Insights into Cancer Pathogenesis

2024-12-19

Abstract excerpt

<title>Abstract</title> <p>The ARID1A gene, frequently mutated in cancer, encodes the AT-rich interactive domain-containing protein 1A, a key component of the chromatin remodeling SWI/SNF complex. The ARID1A protein features a conserved DNA-binding domain (ARID domain) of approximately 100 residues crucial for its function. Despite the frequency of mutations, the impact on ARID1A’s stability and contribution to c...

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Literature Corpus work: 89327c4a-dee0-56d1-bfec-d690b4cfc339
DOI: 10.21203/rs.3.rs-5225582/v1

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