Article

Role of d16HER2 splice variant in breast cancer stem cells

2018-01-01

Abstract excerpt

The transmembrane tyrosine kinase receptor HER2 is overexpressed in about 20% of human breast cancers (BCs). Evidence suggests that the co-existence of the full-length/wild-type HER2 oncoprotein (WTHER2) with its altered isoforms increases the heterogeneity of HER2 overexpressing (HER2+) disease thus affecting its biology and treatment response. We found that ~90% of HER2+ BC patients express a WTHER2 isoform char...

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Literature Corpus work: 88f34577-4a8c-5ac4-b613-08a522556084
DOI: 10.21954/ou.ro.0000cf7a

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