Article

HER2 overexpression initiates breast tumorigenesis non-cell-autonomously by inducing oxidative stress in the tissue microenvironment

2023-08-27

Abstract excerpt

<h4>SUMMARY</h4> HER2 is considered as a driver oncogene responsible for the HER2+ subtype of breast cancer. However, it is still unclear how HER2 induces the oncogenic transformation of breast cancer stem cells (BCSCs) and initiates tumorigenesis during premalignant stage breast cancer. Here, we used clinical samples and mouse models of HER2+ breast cancer to demonstrate that neither BCSCs nor their cell-of-orig...

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Literature Corpus work: ddea91bd-592c-5731-84f3-253a2474f9de
DOI: 10.1101/2023.08.25.554770

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