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Article

Role of exon-16-deleted HER2 in breast carcinomas

1 Mar 2006

Abstract excerpt

A splice variant of the human gene HER2, lacking exon-16 (DeltaHER2) which encodes a small extracellular region, has been described. This altered receptor forms disulfide bond-stabilized homodimers. We report here that the DeltaHER2 splice variant represents about 9% of the HER2 mRNA obtained from most of the 46 breast carcinoma samples with HER2 expression levels ranging from 3+ to 0 by HercepTest. Analysis of...

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Identifiers

PMID: 16601290
DOI: 10.1677/erc.1.01047

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