Article
The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse.
PloS one - 29 Apr 2011
Marchini Cristina, Gabrielli Federico, Iezzi Manuela, Zenobi Santa, Montani Maura, Pietrella Lucia, Kalogris Cristina, Rossini Anna, Ciravolo Valentina, Castagnoli Lorenzo, Tagliabue Elda, Pupa Serenella M, Musiani Piero, Monaci Paolo, Menard Sylvie, Amici Augusto
Abstract excerpt
Several transgenic mice models solidly support the hypothesis that HER2 (ERBB2) overexpression or mutation promotes tumorigenesis. Recently, a HER2 splice variant lacking exon-16 (Δ16HER2) has been detected in human breast carcinomas. This alternative protein, a normal byproduct of HER2, has an increased transforming potency compared to wild-type (wt) HER2 receptors. To examine the ability of Δ16HER2 to transform...
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