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Article

The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.

Oncogene - 24 Nov 2016

Turpin J, Ling C, Crosby E J, Hartman Z C, Simond A M, Chodosh L A, Rennhack J P, Andrechek E R, Ozcelik J, Hallett M, Mills G B, Cardiff R D, Gray J W, Griffith O L, Muller W J

Abstract excerpt

Amplification and overexpression of erbB2/neu proto-oncogene is observed in 20-30% human breast cancer and is inversely correlated with the survival of the patient. Despite this, somatic activating mutations within erbB2 in human breast cancers are rare. However, we have previously reported that a splice isoform of erbB2, containing an in-frame deletion of exon 16 (herein referred to as ErbB2ΔEx16), results in...

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Identifiers

PMID: 27157621
DOI: 10.1038/onc.2016.129
PMCID: PMC5102823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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