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Article

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.

FEBS letters - 19 Jun 2013

Wu Guojin, Peng Ji-Bin

Abstract excerpt

Mutations in with-no-lysine (K) kinase 4 (WNK4) and a ubiquitin E3 ligase complex component kelch-like 3 (KLHL3) both cause pseudohypoaldosteronism II (PHAII), a hereditary form of hypertension. We determined whether WNK4 or its effector is regulated by KLHL3 in Xenopus oocytes. KLHL3 inhibited the positive effect of WNK4 on Na(+)-Cl(-) cotransporter (NCC) by decreasing WNK4 protein abundance without decreasing...

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Source

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Identifiers

PMID: 23665031
DOI: 10.1016/j.febslet.2013.04.032
PMCID: PMC3697765

Genes

WNK4
KLHL3
OSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.PMID 23665031Read ↗

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KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.Semantic proximity Read ↗

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