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Article

Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer.

Cancer research - 2 Mar 2026

Liu Tongyan, Huang Shiyi, Li Zhitong, Li Jianyu, Sun Qinhong, Wang Qinglin, Shen Ziyang, Xia Zhijun, Meng Fanchen, Xu Youtao, Xia Wenjia, Tan Jing, Yin Rong

Abstract excerpt

Drug-tolerant persister (DTP) cells drive therapeutic resistance in EGFR-mutant lung adenocarcinoma. Using single-cell RNA sequencing, we identified a clinically significant RGS5+MYL9+ cancer-associated fibroblast (CAF) population that was associated with EGFR tyrosine kinase inhibitor (TKI) resistance and poor prognosis. These CAFs were recruited to DTP niches via CCL11 signaling, and they formed tunneling...

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Identifiers

PMID: 41329713
DOI: 10.1158/0008-5472.CAN-25-0433
PMCID: PMC13055635

Genes

EGFR
MYL9
RGS5
CCL11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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