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Thymidine kinase 1 through the ages: a comprehensive review

27 Nov 2020

Abstract excerpt

Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular proliferation through the recovery of the nucleotide thymidine in the DNA salvage pathway. TK1 upregulation has been found to be an early event in cancer...

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PMID: 33292474
DOI: 10.1186/s13578-020-00493-1

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