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Article

Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations.

BMC cancer - 20 Mar 2018

Ozaki Toshinori, Yu Meng, Yin Danjing, Sun Dan, Zhu Yuyan, Bu Youquan, Sang Meixiang

Abstract excerpt

BACKGROUND: Despite the remarkable advances in the early diagnosis and treatment, overall 5-year survival rate of patients with pancreatic cancer is less than 10%. Gemcitabine (GEM), a cytidine nucleoside analogue and ribonucleotide reductase inhibitor, is a primary option for patients with advanced pancreatic cancer; however, its clinical efficacy is extremely limited. This unfavorable clinical outcome of...

Topics

Antimetabolites, Antineoplastic
Core Binding Factor Alpha 1 Subunit
Deoxycytidine
Drug Resistance, Neoplasm
Humans
Mutation
Pancreatic Neoplasms
Prognosis
Tumor Suppressor Protein p53
Gemcitabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 29558908
DOI: 10.1186/s12885-018-4217-9
PMCID: PMC5861661

Genes

RUNX2
GEM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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