Article

Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.

2023-11-15

Abstract excerpt

<title>Abstract</title> <p>Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma (PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemcitabine), fluorouracil-based regiments such as FOLFIRINOX regimen (5-fluorouracil (5-FU), oxaliplatin, Irinotecan) and platinum-based regimens, especia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72665df5-138b-544d-8d6a-14bd57b07258
DOI: 10.21203/rs.3.rs-3451706/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.DOI 10.21203/rs.3.rs-3451706/v1Read

E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGASemantic proximity Read

ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancerSemantic proximity Read

KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomasSemantic proximity Read

Epigenetic Activation of the CMTM6‐IGF2BP1‐EP300 Positive Feedback Loop Drives Gemcitabine Resistance in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Integrative Genomic Analysis of Gemcitabine Resistance in Pancreatic Cancer by Patient-derived Xenograft ModelsSemantic proximity Read

The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironmentSemantic proximity Read

Epigenetic drug screening defines a PRMT5 inhibitor–sensitive pancreatic cancer subtypeSemantic proximity Read

Multidrug resistance genes screening of pancreatic cancer based on sensitivity profile to chemotherapeutic drugsSemantic proximity Read

The Landscape of Pancreatic Cancer Therapeutic Resistance MechanismsSemantic proximity Read

The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancerSemantic proximity Read

The challenge of drug resistance in pancreatic ductal adenocarcinoma: a current overviewSemantic proximity Read

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinomaSemantic proximity Read