Article

Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma

2021-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Immune cell composition within the tumor microenvironment is regulated by tumor-derived factors. Cell Communication Network factor 4 (CCN4/WISP1) is a matricellular protein secreted by cancer cells that promotes metastasis by inducing the epithelial-mesenchymal transition. While metastatic dissemination limits patient survival, the absence of anti-tumor immunity also associates with poor patient...

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Literature Corpus work: 88b1ae26-4662-5dd5-8d33-b08afdaeeeb9
DOI: 10.1101/2021.02.23.432584

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