Article

KDM5A-driven H3K4me3 promotes aberrant neural development by Wnt/β-catenin pathway activation

2024-12-02

Abstract excerpt

<title>Abstract</title> <p>Neural tube defects (NTDs) are common and severe birth defects. Folate supplementation can prevent NTDs, but the underlying molecular mechanisms are unclear. Aberrant Wnt/β-catenin pathway activation leads to defective anteroposterior patterning, resulting in NTDs, but little is known about whether epigenetic factors contribute to this process. Here, we performed ChIP and CUT&Tag to exp...

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Literature Corpus work: 88ac1a9c-36ec-5010-90f9-c740a68331c7
DOI: 10.21203/rs.3.rs-5410400/v1

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