Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects

Abstract excerpt

BACKGROUND: Neural tube defects (NTDs) are one of the most severe congenital abnormalities characterized by failures of the neural tube to close during early embryogenesis. Maternal folate deficiency could impact the occurrence of NTDs, however, the mechanisms involved in the cause of NTDs are poorly defined. RESULTS: Here, we report that histone H3 methyltransferase disruptor of telomeric silencing 1-like...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Folate and B Vitamins Research
• Share to Genetic Syndromes and Imprinting
• Share to Hedgehog Signaling Pathway Studies