Article

Folate deficiency facilitates coordination of KDM6A with p53 in response to DNA damage

2019-03-28

Abstract excerpt

Folate contributes to the accumulation of DNA strand breaks (DSBs) in the genome. Kdm6a plays a critical role in early embryogenesis but it is unknown whether Kdm6a is involved in the DNA damage response under folate deficiency. Here, we established a low folate environment for mouse embryonic cells using a folate antagonist (methotrexate, MTX). We found increased enrichment of DSBs in Kdm6a in MTX-treated cells,...

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Literature Corpus work: 200d516f-0d8e-59d6-874f-514e1c9c2700
DOI: 10.1101/591768

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