Article

Multicolor single particle reconstruction of protein complexes

2018-01-28

Abstract excerpt

Single-particle reconstruction (SPR) from electron microscopy images is widely used in structural biology, but lacks direct information on protein identity. To address this limitation, we developed a computational and analytical framework that reconstructs and co-aligns multiple proteins from 2D super-resolution fluorescence images. We demonstrate our method by generating multi-color 3D reconstructions of several...

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Identifiers and source

Literature Corpus work: 887e5565-847f-5291-8481-a9e5601f1170
DOI: 10.1101/255364

Open publication

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