Article

DeepCryoPicker: Fully Automated Deep Neural Network for Single Protein Particle Picking in cryo-EM

2019-09-10

Abstract excerpt

Cryo-electron microscopy (Cryo-EM) is widely used in the determination of the three-dimensional (3D) structures of macromolecules. Particle picking from 2D micrographs remains a challenging early step in the Cryo-EM pipeline due to the diversity of particle shapes and the extremely low signal-to-noise ratio (SNR) of micrographs. Because of these issues, significant human intervention is often required to generate...

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Literature Corpus work: c08cfecb-98c2-57c2-b013-51368b9817bc
DOI: 10.1101/763839

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