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Article

Optineurin regulates the interferon response in a cell cycle-dependent manner.

PLoS pathogens - 1 Apr 2015

Génin Pierre, Cuvelier Frédérique, Lambin Sandrine, Côrte-Real Filipe Josina, Autrusseau Elodie, Laurent Christine, Laplantine Emmanuel, Weil Robert

Abstract excerpt

Viral invasion into a host is initially recognized by the innate immune system, mainly through activation of the intracellular cytosolic signaling pathway and coordinated activation of interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-κB) transcription factors that promote type...

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Share to Deubiquitinating Enzyme CYLD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25923723
DOI: 10.1371/journal.ppat.1004877
PMCID: PMC4414543

Genes

TBK1
CYLD
TANK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25923723-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Optineurin regulates the interferon response in a cell cycle-dependent manner.PMID 25923723Read ↗

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Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.Semantic proximity Read ↗

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