Article

Genetic Background and Sex Modulate Androgen Responses in Human Brain Microphysiological System

2025-12-08

Abstract excerpt

Sex steroids shape human brain development, yet the cellular and molecular consequences of androgen addition need further exploration. Here, we used a human neural organoid model - brain microphysiological system (bMPS), derived from nine induced pluripotent stem cell (iPSC) lines to model the impact of dihydrotestosterone (DHT), a potent non-aromatizable androgen. All lines differentiated reproducibly into electr...

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Literature Corpus work: 886723a9-19a4-5aef-8a65-407ed864ece4
DOI: 10.64898/2025.12.03.692130

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