Article

The ORF6 accessory protein contributes to SARS-CoV-2 virulence and pathogenicity in the naturally susceptible feline model of infection

2025-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Here the infection dynamics, replication, and pathogenicity of a recombinant virus containing a deletion of ORF6 (rWA1ΔORF6) on the backbone of the highly virulent SARS-CoV-2 WA1 virus (rWA1) were investigated and compared to the parental rWA1 virus. While both rWA1 and rWA1ΔORF6 viruses replicated efficiently in cultured cells, the rWA1ΔORF6 virus produced smaller plaques, suggesting reduced ce...

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Literature Corpus work: 884fa6ad-61e4-50e4-88c7-1c8b578b5371
DOI: 10.1101/2025.04.09.647941

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