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Article

The parapoxvirus Orf virus ORF116 gene encodes an antagonist of the interferon response.

The Journal of general virology - 1 Dec 2021

AlDaif Basheer A, Mercer Andrew A, Fleming Stephen B

Abstract excerpt

Orf virus (ORFV) is the type species of the Parapoxvirus genus of the Poxviridae family. Genetic and functional studies have revealed ORFV has multiple immunomodulatory genes that manipulate innate immune responses, during the early stage of infection. ORF116 is a novel gene of ORFV with hitherto unknown function. Characterization of an ORF116 deletion mutant showed that it replicated in primary lamb testis cells...

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PMID: 34890310
DOI: 10.1099/jgv.0.001695

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