Article

The SARS-CoV-2 Spike is a virulence determinant and plays a major role on the attenuated phenotype of Omicron virus in a feline model of infection

2023-10-09

Abstract excerpt

To assess the role of the Omicron BA.1 Spike (S) protein in the pathogenesis of the severe acute respiratory coronavirus 2 (SARS-CoV-2), we generated recombinant viruses harboring the S D614G mutation (rWA1-D614G) and the Omicron BA.1 S gene (rWA1-Omi-S) in the backbone of the ancestral SARS-CoV-2 WA1 strain genome. The recombinant viruses were characterized in vitro and in vivo . Viral entry, cell-cell fusion,...

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Literature Corpus work: b03fc9ea-b3d5-57ca-afbe-6a8cd1dbaace
DOI: 10.1101/2023.10.09.561473

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