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Article

Translational Control of Autophagy by Orb in the Drosophila Germline.

Developmental cell - 7 Dec 2015

Rojas-Ríos Patricia, Chartier Aymeric, Pierson Stéphanie, Séverac Dany, Dantec Christelle, Busseau Isabelle, Simonelig Martine

Abstract excerpt

Drosophila Orb, the homolog of vertebrate CPEB, is a key translational regulator involved in oocyte polarity and maturation through poly(A) tail elongation of specific mRNAs. orb also has an essential function during early oogenesis that has not been addressed at the molecular level. Here, we show that orb prevents cell death during early oogenesis, thus allowing oogenesis to progress. It does so through the...

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Source

Identifiers

PMID: 26625957
DOI: 10.1016/j.devcel.2015.11.003

Genes

CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Translational Control of Autophagy by Orb in the Drosophila Germline.PMID 26625957Read ↗

Orb prevents autophagy in the <i>Drosophila</i> germline through translational repression of <i>Atg12</i> mRNASemantic proximity Read ↗

The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.Semantic proximity Read ↗

Cup blocks the precocious activation of the orb autoregulatory loop.Semantic proximity Read ↗

The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.Semantic proximity Read ↗

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis.Semantic proximity Read ↗

Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesisSemantic proximity Read ↗

Functioning of the Drosophila orb gene in gurken mRNA localization and translation.Semantic proximity Read ↗

Autophagy of an Amyloid-like Translational Repressor Regulates Meiotic ExitSemantic proximity Read ↗

The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.Semantic proximity Read ↗

The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function.Semantic proximity Read ↗

Cell death duringDrosophila melanogasterearly oogenesis is mediated through autophagySemantic proximity Read ↗

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