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Article

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.

Development (Cambridge, England) - 1 Mar 2003

Castagnetti Stefania, Ephrussi Anne

Abstract excerpt

During Drosophila oogenesis, the posterior determinant, Oskar, is tightly localized at the posterior pole of the oocyte. The exclusive accumulation of Oskar at this site is ensured by localization-dependent translation of oskar mRNA: translation of oskar mRNA is repressed during transport and activated upon localization at the posterior cortex. Previous studies have suggested that oskar translation is...

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Identifiers

PMID: 12538512
DOI: 10.1242/dev.00309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.PMID 12538512Read ↗

A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.Semantic proximity Read ↗

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.Semantic proximity Read ↗

oskar mRNA is localized to the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

BREs mediate both repression and activation of oskar mRNA translation and act in trans.Semantic proximity Read ↗

Translational Control of Autophagy by Orb in the Drosophila Germline.Semantic proximity Read ↗

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Semantic proximity Read ↗

Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C.Semantic proximity Read ↗

Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation.Semantic proximity Read ↗

The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo.Semantic proximity Read ↗

Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors.Semantic proximity Read ↗

Cup blocks the precocious activation of the orb autoregulatory loop.Semantic proximity Read ↗

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