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Article

Cup blocks the precocious activation of the orb autoregulatory loop.

PloS one - 1 Jan 2011

Wong Li Chin, Schedl Paul

Abstract excerpt

Translational regulation of localized mRNAs is essential for patterning and axes determination in many organisms. In the Drosophila ovary, the germline-specific Orb protein mediates the translational activation of a variety of mRNAs localized in the oocyte. One of the Orb target mRNAs is orb itself, and this autoregulatory activity ensures that Orb proteins specifically accumulate in the developing oocyte. Orb is...

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Identifiers

PMID: 22164257
DOI: 10.1371/journal.pone.0028261
PMCID: PMC3229553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cup blocks the precocious activation of the orb autoregulatory loop.PMID 22164257Read ↗

Cup regulates oskar mRNA stability during oogenesis.Semantic proximity Read ↗

Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.Semantic proximity Read ↗

Translational Control of Autophagy by Orb in the Drosophila Germline.Semantic proximity Read ↗

Orb prevents autophagy in the <i>Drosophila</i> germline through translational repression of <i>Atg12</i> mRNASemantic proximity Read ↗

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C.Semantic proximity Read ↗

orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis.Semantic proximity Read ↗

The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.Semantic proximity Read ↗

The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes.Semantic proximity Read ↗

The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.Semantic proximity Read ↗

Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation.Semantic proximity Read ↗

Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.Semantic proximity Read ↗

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