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Article

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses

2024-08-28

Abstract excerpt

DPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity with which merbecoviruses engage ACE2 and their receptor species tropism remain unknown. Here, we reveal that HKU5 enters host cells utilizing Pipistrellus abramus (P.abr) and several non-bat mammalian ACE2s through a binding mode distinct from...

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Identifiers and source

Literature Corpus work
8801ab76-fda1-5268-8142-4b1b6c83bb23
DOI
10.1101/2024.08.28.608351
Open publication

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Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronavirusesDOI 10.1101/2024.08.28.608351
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