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Article

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses

7 Feb 2025

Abstract excerpt

DPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity of ACE2 utilization among merbecoviruses and their receptor species tropism remain unknown. Here, we reveal that HKU5 enters host cells utilizing Pipistrellus abramus (P.abr) and several non-bat mammalian ACE2s through a binding mode distinct...

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PMID: 39922192
DOI: 10.1016/j.cell.2024.12.032

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