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Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

15 Jun 2023

Abstract excerpt

Recently, two Middle East respiratory syndrome coronavirus (MERS-CoV) closely related to bat merbecoviruses, NeoCoV and PDF-2180, were discovered to use angiotensin-converting enzyme 2 (ACE2) for entry. The two viruses cannot use human ACE2 efficiently, and their host range and cross-species transmissibility across a wide range of mammalian species remain unclear. Herein, we characterized the species-specific...

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PMID: 37321999
DOI: 10.1038/s41421-023-00566-8

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