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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors

24 Jul 2025

Abstract excerpt

Identifying receptors for bat coronaviruses is critical for spillover risk assessment, countermeasure development, and pandemic preparedness. While Middle East respiratory syndrome coronavirus (MERS-CoV) uses DPP4 for entry, the receptors of many MERS-related betacoronaviruses remain unknown. The bat merbecovirus HKU5 was previously shown to have an entry restriction in human cells. Using both pseudotyped and...

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PMID: 40707428
DOI: 10.1038/s41467-025-61583-7

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