Article

Human mitochondrial DNA variants influence telomere length: evidence from a transmitochondrial cybrid model

2025-07-02

Abstract excerpt

Telomere shortening is a hallmark of aging, yet telomere length (TL) varies considerably among individuals and is strongly influenced by inheritance. In mice, efficient mitochondrial function-characterized by low reactive oxygen species (ROS) production-is critical for telomere elongation during early embryogenesis. Since mitochondrial DNA (mtDNA) encodes several subunits of the electron transport chain, it may in...

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Identifiers and source

Literature Corpus work: 87f807a2-96a3-573c-90bd-53d1962d633b
DOI: 10.1101/2025.06.27.661964

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