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Functional Differences between Mitochondrial Haplogroup T and Haplogroup H in HEK293 Cybrid Cells

26 Dec 2012

Abstract excerpt

BACKGROUND: Epidemiological case-control studies have revealed associations between mitochondrial haplogroups and the onset and/or progression of various multifactorial diseases. For instance, mitochondrial haplogroup T was previously shown to be associated with vascular diseases, including coronary artery disease and diabetic retinopathy. In contrast, haplogroup H, the most frequent haplogroup in Europe, is...

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PMID: 23300652
DOI: 10.1371/journal.pone.0052367

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