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Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization

14 Mar 2025

Abstract excerpt

Abstract The initial setting of telomere length during early life in each individual has a major influence on lifetime risk of aging-associated diseases; however there is limited knowledge of biological signals that regulate inheritance of telomere length, and whether it is modifiable is not known. We now show that when mitochondrial activity is disrupted in mouse zygotes, via exposure to 20% O2 or rotenone,...

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PMID: 40087268
DOI: 10.1038/s41467-025-57794-7

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